Professor Jack C. Ng (Phd, DABT)
Professorial Research Fellow
Phone: +61 (0)429 547 155 or 0414-747-147
Fax: +61 (0)7 3274 9003
The University of Queensland
Faculty of Health Sciences
National Research Centre for Environmental Toxicology (Entox)
39 Kessels Road, Coopers Plains, QLD 4108
PhD – Chemistry and Environmental Toxicology (The University of Queensland), MAppSc (Queensland University of Technology, BAppSc (Queensland University of Technology), DABT (Diplomate of the American Board of Toxicology)
Professor Jack Ng is one of very few certified toxicologists in Australia (DABT - Diplomate of the American Board of Toxicology). Jack started his scientific career as an Industrial Chemist (Beer Analyst) working at the Carlton & United Breweries in Australia. Jack joined the University of Queensland in 1977 and commenced his research career in the Toxicology Laboratory within the Veterinary School. In 1992, Jack moved to the National Research Centre for Environmental Toxicology (Entox) at the Faculty of Health Sciences, the University of Queensland. In his current position of Professorial Research Fellow, Jack is the Program Group Leader for Risk Assessment and Intervention (formerly Metals and Metalloids Research). His major research themes include chemical speciation in environmental and biological media, bioavailability in relationship to toxicities using various animal and cell models, carcinogenicity and mechanistic studies of chronic arsenic toxicity in both humans and animals. Jack and his team were the first to have demonstrated that MMAIII, a methylated trivalent arsenic metabolite, is a carcinogen in an in-vivo mouse model. This is a landmark study in arsenic research in addition to his initial proof of the carcinogenic effect of inorganic arsenic in-vivo. Other research interests include toxicity of mixed metals, the transfer of heavy metals via the food chain from contaminated sites, and natural toxins relevant to human health. The latter is represented by a project focused on management of mycotoxin contamination in maize. More recently, Jack’s PhD student successfully isolated and validated a group of toxins causing Sago haemolytic disease in humans. A food-toxin induced-disease causes mortalities in Papua New Guinea. Jack is also a Program Leader in CRC-CARE (Contamination Assessment and Remediation of the Environment). As a Program Leader he oversees numerous research projects within CRC-CARE.
Jack’s expertise in his field of research has been recognised by World Health Organisation (WHO), International Agency for Research on Cancer, and WHO/FAO Joint Expert Committee on Food Additives as demonstrated by his involvement in a number of monographs and technical reports produced by these agencies. Nationally, Jack was a member of the National Health and Medical Research Council (NHMRC) working committee for the revision of National Environmental Protection Measures (NEPM) Health Investigation Levels; and a member of the project advisory group of the Health Screening Levels for petroleum hydrocarbons that soon will be adopted into the national NEPMs. Jack was the lead author of the technical and guidance documents on “Contaminant Bioavailability and Leachibility”. The latter will form part of the new national NEPM document.
Over the past five years Jack’s research group has attracted several millions Australian dollars of grants. Jack has a career list of more than 300 publications of which over 140 are peer reviewed journal papers, monographs and book chapters.
- Metal and metalloid speciation
- Bioavailability and pharmacokinetics related to toxicity
- Cell-based in-vitro and animal in-vivo toxicology
- Interaction studies on mixed organic and inorganic contaminants
- Food-borne natural toxins
- Environmental toxicology and risk assessment
- Risk intervention strategies
PhD and MPhil Projects
- Andrew McKay – PhD Candidate
- Development of unicellular tool for the toxicity assessment of single and mixture of metals and metalloids.
- Violet Diacomanolis - PhD Candidate
- Mixed metal/metalloid interactions affecting bioavailability with particular reference to mine tailing risk assessment.
- Aisak Pue - PhD Candidate
- Studies in sago haemolytic disease (SHD) compounds production by fungi, their chemical characterisation and use for development for simple rapid assay ELISA detection method.
- Lisa Bricknell - PhD Candidate
- Management of mycotoxin contamination of maize in Australia.
- Huu-Phuc Tran - PhD Candidate
- A Study of Arsenic Carcinogenicity: Its Possible Role Against DNA Repair Mechanism.
- Tracey Howkins (CQU) - PhD Candidate
- Optimal physical, chemical and physiological parameters to maximise the uptake of arsenic by hyper-accumulating ferns.
- Melanie Trenfield - PhD Candidate
- The effect of dissolved organic matter on the toxicity and bioavailability of metals in tropical freshwater ecosystems (awarded 2012)
- Faye Liu – PhD Candidate
- Development of an in vitro cell system for measurement of BTEX toxicology in petroleum hydrocarbons
- Shiva Prakash – PhD Candidate
- Development of an in vitro cell system for real time measurment of toxicological effects of petroleum hydrocarbons
- Raijeli Taga – PhD Candidate
- Development of in vitro methods to predict bioavailability of arsenic, cadmium, copper, lead and zinc in mine wastes for human health risk assessment
- Raghad Nathom Alsaadi – PhD Candidate
- Evaluation of copper and zinc cyanide complexes toxicity using Euglena gracilis Z &SMZ as an in vitro model
- Jia Jia Zheng – PhD Candidate
- Pathways of lead exposure in a mining town
- Homa Teimouri Sichani – MPhil Candidate
- In-vitro toxicity evaluation of free cyanide and strong metal cyanide complexes related to mining
Examples of Peer Reviewed Scientific Publications
- A’edah Abu-Bakar, Dionne M. Arthur, Anna S. Wikman, Minna Rahnasto, Risto O. Juvonen, Jouko Vepsalainen, Hannu Raunio, Jack C. Ng, Matti Lang (2012) Metabolism of bilirubin by human cytochrome P450 2A6. Toxicology and Applied Pharmacology. 261, 50-58.
- Melanie A. Trenfield, Jack C. Ng, Barry N. Noller, Scott J. Markich, and Rick A. van Dam (2011). Dissolved Organic Carbon Reduces Uranium Bioavailability and Toxicity. 1. Characterization of an Aquatic Fulvic Acid and Its Complexation with Uranium[VI]. Environ. Sci. Technol. 45, 3075-3081.
- Melanie A. Trenfield, Jack C. Ng, Barry N. Noller, Scott J. Markich, and Rick A. van Dam (2011). Dissolved Organic Carbon Reduces Uranium Bioavailability and Toxicity. 2. Uranium[VI] Speciation and Toxicity to Three Tropical Freshwater Organisms. Environ. Sci. Technol. 45, 3082-3089.
- Diacomanolis, V; Ng, JC; Sadler, R; Nomura, M; Noller, BN; Harris, HH (2010). Consistent Chemical Form of Cd in Liver and Kidney Tissues in Rats Dosed with a Range of Cd Treatments: XAS of Intact Tissues. Chemical Research In Toxicology 23 (11): 1647-1649.
- Wang, J. P., Maddalena, R., Zheng, B., Zai, C., Liu, F. and Ng, J. C. (2009) Arsenicosis status and urinary malondialdehyde (MDA) in people exposed to arsenic contaminated-coal in China. Environment International, 35 3: 502-506.
- Wang, J. P., Wang, S. L., Lin, Q., Zhang, L., Huang, D. and Ng, J. C. (2009) Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats. Environment International, 35 3: 507-511.
- Melissa Haswell-Elkins, Soisungwan Satarug, Peter O’Rourke, Michael Moore, Jack Ng, Victor McGrath, Maria Walmby (2008). Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes. Environmental Research. 106: 379-383.
- Abul Hasnat, M., Smith, W., Dear, K., Ng, J. C., Sim, M., Ranmuthugala, G., Lokuge, K., Caldwell, B., Rahman, A., Rahman, H., Shraim, A., Huang, D. and Shahidullah, S. M. (2007) A Randomised intervention trial to assess two arsenic mitigation options in Bangladesh. Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering, 42 12: 1897-1908.
- Scott Bruce, Barry Noller, Vitukawalu Matanitobua, Jack Ng (2007). In-vitro physiologically-based extraction test (PBET) and bioaccessibility of arsenic and lead from various mine waste materials. Journal of Toxicology and Environmental Health, Part A. 70: 1700-1711.
- Ng J.C., Wang J.P., Zheng B.S., Zhai C., Maddalena R., Liu F. Moore M.R. (2005). Urinary porphyrins as biomarkers for arsenic exposure among susceptible populations in Guizhou province, China. Toxicol. Appl. Pharmacol, 206(2): 176-184.
Examples of Technical Publications & Monographs
- Ng, J.C. (one of many authors) (2011) Evaluation of Certain Contaminants in Food. Seventy-Second Report of the Joint FAO/WHO Expert Committee on Food Additives (acrylamide, arsenic, Deoxynivalenol (DON), furan, mercury, perchlorate), WHO Technical Report Series 959, ISBN 978 92 4 120959 5., ISSN 0512-3054, NLM classification: WA 701, WHO. Pp1-115.
- Ng, J.C., Juhasz, A.L., Smith, E., Naidu, R. (2010) Contaminant bioavailability and bioaccessibility: Part 1. Scientific and Technical Review (74pp). 2. Guide for Industry (pp11). CRC CARE Technical Report 14. CRC for Contamination Assessment and Remediation of the Environment, Adelaide, Australia. pp1-74.
- Barry N Noller, Vitukawalu P. Matanitobua and Jack C. Ng (2009). Phase 1 Study of Heavy Metals and Metalloids in the Leichhardt River and surrounding locations: Lead Pathways Study - Phase 1 (Emissions to Land). Prepared for Mount Isa Mines Ltd. 126pp. (Phase 2 – water & sediment; and phase 3 – pathways and health) reports are being completed in 2012).
- Jack C. Ng, Violet Diacomanolis, Barry N. Noller (2006). Site Specific Health Risk Assessment of Arsenic, Lead and other Metals at Woodcutters Mine site. A technical report prepared for Newmont Australia Ltd. Pp1-92.
- Costanzo, S., Bruce, S., Chapman, H., Gaus, C., Leontjew-Toms, L., Moore, M., Müller, J., Ng, J., Paxman, C., Stephens, S., 2004. Reference Guide - Guidelines and Standards for Chemicals in the Australian Environment. Department of the Environment and Heritage, Environment Australia, Sydney, Australia (Database).
- Anders, W.M, Bull, R.J., Cantor, K.P., Chakraborti, D., Chen, C., DeAngelo, A.B., DeMarini, D.M., Ferreccio, C., Fukushima, S., Gebel, T.W., Mazumder, D.N., Karagas, M.R., Kogevinas, M., Komulainen, H., Le Curieux, F., Meharg, A., Ng, J.C., Nieuwenhuijsen, M.J., Olin, S., Pereira, M., Rahman, M., Roberson, J.A., Smith, A.H. and Vahter, M. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Geneva, Switzerland: World Health Organization, 2004.
- Bruce S.L., Noller B.N., Grigg A., Mullen B., Mulligan D., Ritchie P.J., Currey N., Ng J.C. (2002). A field study to evaluate the impact of arsenic and lead from mine tailings to grazing cattle. A Report to Kidston Gold Mine. 85pp.
- Ng J.C., Noller B., Bruce S., Moore M.R. (2002). Bioavailability of metals and arsenic at contaminated sites from cattle dips, mined land and naturally occurring mineralisation origins. NEPC Workshop, Adelaide, May, 2002. 22pp.
- Ng J.C. (Co-ordinating Editor & one of several authors). IPCS Environmental Health Criteria document on “Arsenic and arsenic compounds”, EHC 224, WHO, Geneva. Pp521.
- Ng JC (2000) Toxicology and Indoor Air Quality. In: Indoor Air Quality – A Report on Health Impacts and Management Options. Commonwealth of Australia, Department of Health and Aged Care, Canberra, ACT, Australia. ISBN 0642446679. Pp 123-131.